Effect of OPRM1/COMT gene polymorphisms on sufentanil labor analgesia: a cohort study based on propensity score matching
Yao Chen, Quanyao Chen, Can Cai, Xiuxian Lin, Weiwei Yu, Huiqiong Huang, Wenmin Xie, Min Lin, Weida Chen, Hui Wu, Tingting Su, Lingsong Wang- Pharmacology
- Genetics
- Molecular Medicine
Background: This study investigated the use of COMT G1947A and OPRM1 A118G polymorphisms as predictive markers for sufentanil epidural analgesia. Methods: The visual analogue scale (VAS) score, and sufentanil consumption of 136 pairs of parturients using sufentanil with lidocaine and ropivacaine for epidural analgesia were used for analysis. Results: OPRM1 AG/GG had lower VAS score difference between fifth and 0 min (1.55 vs 1.87; p = 0.012) and higher consumption (19.65 μg vs 17.11 μg; p = 0.049) than AA carriers. COMT GA/AA had higher VAS score difference than GG carriers (1.86 vs 1.55; p = 0.021). Conclusion: Sufentanil may provide better epidural labor analgesia in OPRM1 AA and COMT GA/AA carriers compared with OPRM1 AG/GG and COMT GG carriers.
Clinical Trial Registration: ChiCTR1900026897 (Chinese Clinical Trial Center Registry)