Dysbiosis of the Gut microbiota was improved after 24‐week multidomain intervention program to prevent dementia: Subgroup Analysis of SUPERBRAIN study
Woorim Kang, Yoo Kyoung Park, Jee Hyang Jeong, So Young Moon, Hong‐Sun Song, Sun Min Lee, Muncheong Choi, Kyung Won Park, Byeong‐Chae Kim, Soo Hyun Cho, Seong Hye Choi, Chang Hyung Hong, Hae Ri Na- Psychiatry and Mental health
- Cellular and Molecular Neuroscience
- Geriatrics and Gerontology
- Neurology (clinical)
- Developmental Neuroscience
- Health Policy
- Epidemiology
Abstract
Background
The stability of intestinal microbiota is critical to maintaining the integrity of epithelial barrier and immune homeostasis. Thereby, the disruptions to this balance and resulting dysbiosis are often associated with inflammation and compromised barrier function and may cause several kinds of diseases. There is growing evidence that people with Alzheimer’s may have different internal microorganisms than those who do not. We aimed to investigate gut microbiota changes after a 24‐week multidomain lifestyle intervention program in the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at‐risk elderly people (SUPERBRAIN).
Method
Participants without dementia and with at least one modifiable dementia risk factor, aged 60‐79 years, were randomly assigned to the facility‐based multidomain intervention (FMI) (n = 51), the home‐based multidomain intervention (HMI) (n = 51), and the control group (n = 50). Demographic and clinical factors were assessed as well as the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were evaluated as neuropsychological tests both at baseline and at the end of the study. Stool samples were collected for analysis of 16S rRNA gene sequencing, taxonomic profiling, and functional profiling.
Result
Participants who received either the facility‐based (5.4 ±7.7 increase) or home‐based (5.4 ±8.2 increase) intervention showed significantly increased RBANS scores compared to the control (0.03 ± 9.3 increase). The Beta‐diversity analysis showed significant differences in the microbial composition between the intervention group and control group. Also, participants who received multidomain intervention showed decreased proteobacteria abundance and increased abundance of Lachnospira, Parabacteroides.
Conclusion
In conclusion, the present study suggest that multidomain intervention in elderly with high risk of dementia not only showed beneficial effect on neuropsychological status but also improving the dysbiosis of gut microbiome