Jun-Rong Song, Xiong-Jiang Li, Jun Shi, Qin Chi, Wei Wu, Hai Ren

Direct synthesis of N-functionalized indoles through isomerization of azomethine ylides

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

A general additive-free strategy based on the isomerization of azomethine ylides generated in situ from isatin and indoline-2-carboxylic acid has been disclosed, providing direct access to N-functionalized indole scaffolds.

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