DOI: 10.1002/cbdv.202301655 ISSN: 1612-1872
Cytotoxic withanolides from the leaves of Datura stramonium L.
Juan Pan, Yan Liu, Xin-Yuan Li, Si-Yi Wang, Jia-Tong Wu, Meng-Meng Li, Wei Guan, Adnan Mohammed Algradi, Hai-Xue Kuang, Bing-You Yang- Molecular Biology
- Molecular Medicine
- General Chemistry
- Biochemistry
- General Medicine
- Bioengineering
Six novel withanolides, along with nine known related compounds were isolated from the leaves of Datura stramonium L. The structures and absolute configurations of the new withanolides were elucidated by employing various spectral techniques and comparing them with those previously reported in the literature. In addition, four withanolides demonstrated interesting cytotoxic activity on LN229 cells with IC50<20 μM.