DOI: 10.3390/dermatopathology10030034 ISSN:
Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis
Cesare Ariasi, Carola Romanò, Iacopo Ghini, Gaetano Licata, Luca Rubelli, Grazia Linda Artelli, Piergiacomo Calzavara-Pinton, Mariachiara Arisi- General Engineering
Cutaneous syncytial myoepithelioma (CSM) is a rare type of cutaneous neoplasm that typically presents as a solitary and well-circumscribed nodule on the skin. It predominantly occurs on the upper and lower extremities of adult patients. Immunohistochemically, CSM is characterized by the co-expression of smooth muscle and epithelial markers. Fluorescence in situ hybridization (FISH) targeting the EWSR1 gene rearrangement is an important diagnostic tool for CSM. In our case report, we found the focal positivity for CD34, which has never been previously observed; this was mostly confined to a central area of the neoplasm.