Jiale Zhang, Xue Liu, Qixuan Mu, Ruijun Li, Yibing Ji

Construction and Application of a Pepsin‐Functionalized Covalent Organic Framework with Prominent Chiral Recognition Ability

  • General Chemistry
  • Catalysis
  • Organic Chemistry
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The stable Pepsin@covalent organic framework (Pepsin@COF) were constructed base on matching COF pore diameter to pepsin dimension. It exhibits excellent chiral recognition capabilities (e.e.% up to 62.63%) and potential for enantioseparation. Furthermore, a positive correlation between the immobilized enzyme activity and chiral recognition was revealed, offering insights for the design of biocatalytic nanosystems in chiral separation.

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