DOI: 10.1039/d3sc02857g ISSN: 2041-6520
Computationally guided bioengineering of the active site, substrate access pathway, and water channels of thermostable cytochrome P450, CYP175A1, for catalyzing the alkane hydroxylation reaction
Mohd Taher, Kshatresh Dutta Dubey, Shyamalava Mazumdar- General Chemistry
Rational design and engineering of the active pocket for access and binding of the substrate, and water channel in a thermostable cytochrome P450 enabled efficient catalysis of a longer chain alkane.