DOI: 10.1111/jmp.12674 ISSN:

Characterizing the phenotypic and genetic changes of pre‐epidemic HIV‐2 group F virus following serial passage in humanized mice

James Z. Curlin, Kimberly Schmitt, Leila Remling‐Mulder, Corina Valencia Tibbitts, Shelby O'Connor, Preston Marx, Ramesh Akkina
  • General Veterinary
  • Animal Science and Zoology


HIV‐2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu‐mice showed increased viral loads, CD4+ T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.

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