DOI: 10.1111/jmp.12674 ISSN:
Characterizing the phenotypic and genetic changes of pre‐epidemic HIV ‐2 group F virus following serial passage in humanized mice
James Z. Curlin, Kimberly Schmitt, Leila Remling‐Mulder, Corina Valencia Tibbitts, Shelby O'Connor, Preston Marx, Ramesh Akkina - General Veterinary
- Animal Science and Zoology
Abstract
HIV‐2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu‐mice showed increased viral loads, CD4+ T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.