DOI: 10.1128/aac.00194-23 ISSN: 0066-4804

Cefiderocol Treatment for Patients with Multidrug- and Carbapenem-Resistant Pseudomonas aeruginosa Infections in the Compassionate Use Program

Michael J. Satlin, Patricia J. Simner, Christine M. Slover, Yoshinori Yamano, Tsutae D. Nagata, Simon Portsmouth
  • Infectious Diseases
  • Pharmacology (medical)
  • Pharmacology
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Cefiderocol is an option for infections caused by multidrug-resistant Pseudomonas aeruginosa , but its in vitro activity against these isolates and its clinical effectiveness for isolates with MICs of >1 μg/mL is unclear. We investigated the in vitro activity of cefiderocol against P. aeruginosa isolates collected from patients treated with cefiderocol through the compassionate use program and assessed physician-reported clinical response and 28-day all-cause mortality by cefiderocol MIC values. P. aeruginosa isolates underwent susceptibility testing to cefiderocol and comparator agents by using reference broth microdilution.

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