Eliyas Asfaw, Asiyah Yu Lin, Anthony Huffman, Siqi Li, Madison George, Chloe Darancou, Madison Kalter, Nader Wehbi, Davis Bartels, Elyse Fleck, Nancy Tran, Daniel Faghihnia, Kimberly Berke, Ronak Sutariya, Farah Reyal, Youssef Tammam, Bin Zhao, Edison Ong, Zuoshuang Xiang, Virginia He, Justin Song, Andrey I Seleznev, Jinjing Guo, Yuanyi Pan, Jie Zheng, Yongqun He

CanVaxKB: a web-based cancer vaccine knowledgebase

  • Cancer Research
  • Oncology

Abstract Cancer vaccines have been increasingly studied and developed to prevent or treat various types of cancers. To systematically survey and analyze different reported cancer vaccines, we developed CanVaxKB (https://violinet.org/canvaxkb), the first web-based cancer vaccine knowledgebase that compiles over 670 therapeutic or preventive cancer vaccines that have been experimentally verified to be effective at various stages. Vaccine construction and host response data are also included. These cancer vaccines are developed against various cancer types such as melanoma, hematological cancer, and prostate cancer. CanVaxKB has stored 263 genes or proteins that serve as cancer vaccine antigen genes, which we have collectively termed ‘canvaxgens’. Top three mostly used canvaxgens are PMEL, MLANA and CTAG1B, often targeting multiple cancer types. A total of 193 canvaxgens are also reported in cancer-related ONGene, Network of Cancer Genes and/or Sanger Cancer Gene Consensus databases. Enriched functional annotations and clusters of canvaxgens were identified and analyzed. User-friendly web interfaces are searchable for querying and comparing cancer vaccines. CanVaxKB cancer vaccines are also semantically represented by the community-based Vaccine Ontology to support data exchange. Overall, CanVaxKB is a timely and vital cancer vaccine source that facilitates efficient collection and analysis, further helping researchers and physicians to better understand cancer mechanisms.

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