Lijin Xu, Boxia Xu, Ji Yang, Zhen Yao, Zhuo Yang, Kai Liu, Xing Jin, Qian Shi

B(C6F5)3‐Catalyzed N‐Allylation of Hydrazines with Allylic Alcohols

  • General Chemistry

A N‐allylation of monosubstituted acyl hydrazines with allylic alcohols has been developed by using B(C6F5)3 catalysis. This protocol allows for convenient access to various synthetically useful N‐allylated hydrazine products in 48‐96% yields with broad substrate scope and wide functional group compatibility. The operationally simple reaction proceeds without calling for stringent removal of air and moisture, and can be readily scaled up to gram scale. Preliminary mechanistic studies support that the generation of an allylic carboncation is involved in the catalytic cycle, and the reaction proceeds via the in situ formation of diallyl ethers as intermediates.

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