DOI: 10.1002/psp4.13088 ISSN: 2163-8306
Bayesian estimation in NONMEM
Curtis K. Johnston, Timothy Waterhouse, Matthew Wiens, John Mondick, Jonathan French, William R. Gillespie - Pharmacology (medical)
- Modeling and Simulation
Abstract
Bayesian estimation is a powerful but underutilized tool for answering drug development questions. In this tutorial, the principles of Bayesian model development, assessment, and prior selection will be outlined. An example pharmacokinetic (PK) model will be used to demonstrate the implementation of Bayesian modeling using the nonlinear mixed‐effects modeling software NONMEM.