Ali M. A. Al-Kufaishi, Abtisam F. Al-Shukry, Noor J.T. Al-Musawi

Assessment of IL-6, MDA, GSH and Serum Electrolytes in Diabetic Patients

  • Pharmacology

Background: The public health community has been paying a lot of attention to metabolic syndrome, sometimes known as diabetes mellitus (DM). In many cases for the patients with type 2 diabetes mellitus characterized by an uncontrolled rise in blood sugar (hyperglycemia) brought on by an inability of the body's cells (such as muscles) to detect and utilize the circulating insulin, a condition known as insulin sensitivity or insulin resistance, or by an insulin deficiency. (caused by pancreatic beta cell damage or decreased insulin release). These cases are accompanied by systematic inflammation in the long term, and as a result of the immune effect, there will be an increase in the levels of lipids peroxidation and thus a decrease in the levels of antioxidants. Objective: The study includes an evaluation of inflammatory levels and oxidative stress through an assay of IL-6, malondialdehyde, glutathione, and serum electrolyte levels in the patients with uncontrolled type 2 diabetes mellitus compared with the control. Methods: The case-control study, where ablood sample collections from patients with uncontrolled type 2 diabetes mellitus and control apparently healthy. The samples were analyzed by ELISA, spectrophotometers, and electro-analyzer apparatus. Results: It was found that patients with uncontrolled type 2 diabetes have lower-grade inflammation, which is the reason for the significant increase in interleukin-6 (215±13 Pg/mL) compared with healthy (50±10 Pg/mL). Also, the high levels of free radicals and peroxides can be expressed by the increase in malondialdehyde, as well as a significant reduction in the levels of glutathione value. Patients with uncontrolled type 2 diabetes suffer from electrolyte disturbances due to excessive urine caused by high osmolality and metabolic acidosis due to high ketone bodies and consequently high potassium levels (hyperkalemia) (6.7±0.59 mmol/L). Conclusion: Uncontrolled high diabetes in type 2 patients leads to high inflammatory levels in the body, and this is the reason for increase interleukin 6 levels. Inflammations caused by the immune effect resulting from diabetes lead to the synthesis of higher levels of free radicals, leading to the oxidation of lipids and a decrease of glutathione concentration.

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