Tibor G. Halmagyi, Nizar B. Alsharif, Mohamed A. Berkal, Mark A. Hempenius, Istvan Szilagyi, Julius G. Vancso, Corinne Nardin

Aptamer Clicked Poly(ferrocenylsilanes) at Au Nanoparticles as Platforms with Multiple Functions

  • General Chemistry
  • Catalysis
  • Organic Chemistry
Save to CiteDrive Show PDF

Aptamers are widely used in biosensing due to their specific sensitivity toward many targets. Thus, gold nanoparticle (AuNP) aptasensors are subject to intense research due to the complementary properties of aptamers as sensing elements and AuNPs as transducers. We present herein a novel method for the functional coupling of thrombin‐specific aptamers to AuNPs via an anionic, redox‐active poly(ferrocenylsilane) (PFS) polyelectroyte. The polymer acts as a co‐reductant and stabilizer for the AuNPs, provides grafting sites for the aptamer, and can be used as a redox sensing element, making the aptamer‐PFS‐AuNP composite (aptamer‐AuNP) a promising model system for future multifunctional sensors. The aptamer‐AuNPs exhibit excellent colloidal stability in high ionic strength environments owing to the combined electrosteric stabilizing effects of the aptamer and the PFS. The synthesis of each assembly element is described, and the colloidal stability and redox responsiveness is studied. As an example to illustrate applications, we present results for thrombin sensitivity and specificity using the specific aptamer.

Need a simple solution for managing your BibTeX entries? Explore CiteDrive!

  • Web-based, modern reference management
  • Collaborate and share with fellow researchers
  • Integration with Overleaf
  • Comprehensive BibTeX/BibLaTeX support
  • Save articles and websites directly from your browser
  • Search for new articles from a database of tens of millions of references
Try out CiteDrive

More from our Archive