ANALYSIS OF THE EFFECTIVENESS OF THE USE OF ECHINACEA PURPUREA TINCTURE ON THE THYROID GLAND DURING PROLONGED TOLUENE INTOXICATION OF THE RAT BODY AT VARIOUS AGE PERIODS

The article substantiates the high efficiency of the daily two-month use of Echinacea purpurea tincture at a dose of 200 mg / kg for the purpose of pharmacological correction of thyroid changes to relieve the toxic effects of toluene. A decrease in both absolute and relative thyroid gland mass was recorded, and in immature rats due to a decrease in both lobes, and in rats of reproductive and senile changes, mainly due to the right lobe. After the combined effect of toluene and tincture of echinacea purpurea, the growth is restored and the recovery rate of linear indicators of both thyroid lobes increases, most intensively in the immature period. Changes in histomorphometric parameters indicate the predomi-nance of the effects of echinacea purpurea tincture over toluene, which manifests itself in the normal-ization of the nuclear cytoplasmic index, an increase in the height of thyrocytes, a decrease in the av-erage diameter and colloid accumulation index in the follicles, recorded for two weeks at the early stages of postnatal ontogenesis and for one week in the late period. At the ultramicroscopic level, the structural components of thyrocytes are characterized by better preservation and activation of regener-ative processes, which intensify a month after the completion of toluene intoxication and the introduc-tion of a corrector.