DOI: 10.1111/dom.15465 ISSN: 1462-8902

Age‐ and gender‐adjusted estimated glomerular filtration rate definition reveals hyperfiltration as a risk factor for renal function deterioration in type 2 diabetes

Wei‐Lun Wen, Yau‐Jiunn Lee, Der‐Wei Hwu, Yu‐Hung Chang
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine



To assess the role of hyperfiltration for diabetic kidney disease (DKD) progression.

Materials and Methods

A retrospective observational cohort study enrolled type 2 diabetes (T2D) patients with an initial estimated glomerular filtration rate (eGFR) of 60 mL/min/1.73m2 or higher. Patients were categorized into two groups: hyperfiltration (eGFR exceeding the age‐ and gender‐specific 95th percentile values from a prior national cohort study) and normofiltration. Rapid DKD progression was defined as an eGFR decline of more than 5 mL/min/1.73m2/year. We used a linear mixed effect model and Cox regression with time‐varying covariate model to compare eGFR changes and identify factors associated with rapid DKD progression.


Of the enrolled 7563 T2D patients, 7.2% had hyperfiltration. The hyperfiltration group exhibited a higher rate of eGFR decline compared with the normofiltration group (−2.0 ± 0.9 vs. −1.1 ± 0.9 mL/min/1.73m2/year; P < .001). During an average follow‐up period of 4.65 ± 3.86 years, 24.7% of patients with hyperfiltration experienced rapid DKD progression, compared with 15.7% of patients with normofiltration (P < .001). Cox regression analyses identified that initial hyperfiltration was a significant determinant of rapid DKD progression, with a hazard ratio of 1.66 (95% confidence interval: 1.41‐1.95; P < .001). When combined with albuminuria, the risk of progression was further compounded (hazard ratio 1.76‐3.11, all P < .001).


In addition to using the current Kidney Disease: Improving Global Outcomes CGA classification system, considering glomerular hyperfiltration status can improve the accuracy of predicting DKD progression.

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