DOI: 10.1097/icb.0000000000001529 ISSN: 1935-1089

Acute atrophic evolution of drusenoid pigment epithelium detachment after photobiomodulation

Maurizio Battaglia Parodi, Alessio Antropoli, Alessandro Arrigo, Maria Vittoria Cicinelli, Lorenzo Bianco, Andrea Saladino, Enea Moretti MsC, Francesco Bandello, Ahmad Mansour
  • Ophthalmology
  • General Medicine


To report the acute onset of macular atrophy soon after photobiomodulation (PBM) administration in a patient with intermediate age-related macular degeneration (AMD).


Optical coherence tomography (OCT) was performed in the study eye before and after PBM.


A patient with drusenoid pigment epithelium detachment (D-PED) underwent PBM. A few weeks after PBM the D-PED collapsed, resulting in incomplete retinal pigment epithelium and outer retinal atrophy with visual acuity worsening.


Thinning of the outer retinal layers over a D-PED and posterior hypertrasmission may represent bad prognostic factors for PBM, accelerating the lesion’s natural history towards atrophic evolution.

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