Simulation-based metamodels or surrogate models are simplified models that capture the relationship between inputs and outputs of the simulation model. The analytical expression of metamodels is defined using a sample of input/output points obtained from the simulation model. This analytical expression is then embedded in an optimization process that usually provides solutions much faster than other simulation-based optimization techniques such as metaheuristics or mathematical modeling. The goal of this paper is to describe the simulation-based metamodeling approach and to provide a thorough review of the literature on its applications to emergency healthcare systems. For this purpose, we examine the recent literature (journals and conference proceedings) published in the last 15 years (2008–2022). Finally, we identify findings and avenues of research in simulation-based metamodeling that deserve special attention from the scientific community and allow the potential of this approach to be used for better decision-making in emergency healthcare.

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