DOI: 10.3390/jof9090884 ISSN:

A Phylogeographic Description of Histoplasma capsulatum in the United States

Ujwal R. Bagal, Lalitha Gade, Kaitlin Benedict, Victoria Howell, Natalie Christophe, Suzanne Gibbons-Burgener, Sara Hallyburton, Malia Ireland, Stephanie McCracken, Alison Keyser Metobo, Kimberly Signs, Kimberly A. Warren, Anastasia P. Litvintseva, Nancy A. Chow
  • Plant Science
  • Ecology, Evolution, Behavior and Systematics
  • Microbiology (medical)

Histoplasmosis is one of the most under-diagnosed and under-reported endemic mycoses in the United States. Histoplasma capsulatum is the causative agent of this disease. To date, molecular epidemiologic studies detailing the phylogeographic structure of H. capsulatum in the United States have been limited. We conducted genomic sequencing using isolates from histoplasmosis cases reported in the United States. We identified North American Clade 2 (NAm2) as the most prevalent clade in the country. Despite high intra-clade diversity, isolates from Minnesota and Michigan cases were predominately clustered by state. Future work incorporating environmental sampling and veterinary surveillance may further elucidate the molecular epidemiology of H. capsulatum in the United States and how genomic sequencing can be applied to the surveillance and outbreak investigation of histoplasmosis.

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