A Metal‐Free System for Conversion of Alcohols to Amides using tert‐Butyl Nitrite

doi:10.1002/ajoc.202300576

Harish K Indurthi, Samarpita Das, Pallavi Saha, Deepak Sharma

A Metal‐Free System for Conversion of Alcohols to Amides using tert‐Butyl Nitrite

Organic Chemistry

: A transition metal‐free cascade synthesis of amides from alcohols was developed. Various alcohols reacted with N‐hydroxyimides by tert‐butyl nitrite to generate N‐hydroxyimide esters. The resulting active esters were subsequently reacted with amines to generate amides in one pot. Further, we have illustrated the application of developed protocol in the synthesis of anti‐Alzheimer compounds. A detailed mechanistic exploration was also carried out

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A Metal‐Free System for Conversion of Alcohols to Amides using tert‐Butyl Nitrite

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