DOI: 10.1111/iwj.14554 ISSN: 1742-4801

A meta‐analysis examining the impact of intrawound treatment on reducing deep surgical site infections during instrumented spine surgery

Liqiang Zhou, Shuxing Xing
  • Dermatology
  • Surgery


The purpose of the meta‐analysis was to evaluate and compare the effect of intrawound management on decreasing deep surgical site infections (SSIs) in instrumented spinal surgery (SS). The results of this meta‐analysis were analysed, and the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) were calculated using dichotomous or contentious random or fixed effect models. For the current meta‐analysis, 29 examinations spanning from 2006 to 2022 were included, encompassing 11 181 people who had instrumented SS. Intrawound management had a significantly lower deep SSI when using vancomycin (OR, 0.34; 95% CI, 0.25–0.44, p < 0.001) and povidone‐iodine as intrawound management (OR, 0.24; 95% CI, 0.13–0.42, p < 0.001) compared to control in instrumented SS subjects. The data that was looked at showed that using vancomycin and povidone‐iodine as intrawound management had a much lower deep SSI than using a control group of instrumented SS subjects. However, given that some studies included a small number of subjects, attention should be given to their values.

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