AbstractPhysalis Calyx seu Fructus (PCF) is a herb widely used in China for its function of clearing heat and detoxifying, benefitting the pharynx and reducing phlegm, both in health care and in tea drinking. However, the quality of its fruit and calyx is uneven and the storage period is short. Therefore, it is crucial to develop other parts of PCF with longer storage periods and obvious medicinal effects. Firstly, high‐performance liquid chromatography was used to develop the fingerprint of different parts of PCF, and various chemometric analyses were conducted to screen out chemical markers. The calyxes of PCF were found to cluster together, distinct from the fruits, roots, stems and leaves. The active components of PCF were concentrated in the persistent calyxes, and flavonoids were mainly found in the persistent calyxes and leaves. Secondly, the extraction of persistent calyxes showed the strongest scavenging ability of DPPH and ABTS. Finally, the important chemical markers were verified by network pharmacological analysis and molecular docking. It provides a reference for the clinical application of PCF, and the obtained chemical markers offer a scientific basis for quality evaluation.

More from our Archive

• DOI: 10.3390/antiox12071379 2023

  Oxidative Stress and Antioxidants in Age-Related Macular Degeneration

  Neetu Kushwah, Kiran Bora, Meenakshi Maurya, Madeline C. Pavlovich, Jing Chen

• DOI: 10.3390/bios13070725 2023

  Bisphenol A Imprinted Electrochemical Sensor Based on Graphene Quantum Dots with Boron Functionalized g-C3N4 in Food Samples

  Haci Ahmet Deveci, Müge Mavioğlu Kaya, İnan Kaya, Bahar Bankoğlu Yola, Necip Atar, Mehmet Lütfi Yola

• DOI: 10.3390/antiox12071413 2023

  Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds

  Aparna Agarwal, Rizwana, Abhishek Dutt Tripathi, Tarika Kumar, Kanti Prakash Sharma, Sanjay Kumar Singh Patel

• DOI: 10.3390/antiox12071371 2023

  Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy

  Mira Hammad, Mohammad Raftari, Rute Cesário, Rima Salma, Paulo Godoy, S. Noushin Emami, Siamak Haghdoost

• DOI: 10.3390/bios13070742 2023

  Electrochemical Immunosensors Developed for Amyloid-Beta and Tau Proteins, Leading Biomarkers of Alzheimer’s Disease

  Abhinav Sharma, Lúcio Angnes, Naghmeh Sattarahmady, Masoud Negahdary, Hossein Heli

• DOI: 10.3390/antiox12071436 2023

  Ferulic, Sinapic, 3,4-Dimethoxycinnamic Acid and Indomethacin Derivatives with Antioxidant, Anti-Inflammatory and Hypolipidemic Functionality

  Panagiotis Theodosis-Nobelos, Georgios Papagiouvannis, Eleni A. Rekka

• DOI: 10.3390/diagnostics13142379 2023

  Histopathological Images Analysis and Predictive Modeling Implemented in Digital Pathology—Current Affairs and Perspectives

  Mihaela Moscalu, Roxana Moscalu, Cristina Gena Dascălu, Viorel Țarcă, Elena Cojocaru, Ioana Mădălina Costin, Elena Țarcă, Ionela Lăcrămioara Șerban

• DOI: 10.1002/jcp.31076 2023

  Decoding hepatocarcinogenesis from a noncoding RNAs perspective

  Mostafa K. Abd El‐Aziz, Alyaa Dawoud, Caroline J. Kiriacos, Sherif Ashraf Fahmy, Nadia M. Hamdy, Rana A. Youness

• DOI: 10.3390/antiox12071414 2023

  Simulated Gastrointestinal Digestion of Chestnut (Castanea sativa Mill.) Shell Extract Prepared by Subcritical Water Extraction: Bioaccessibility, Bioactivity, and Intestinal Permeability by In Vitro Assays

  Diana Pinto, Ana Margarida Silva, Stefano Dall’Acqua, Stefania Sut, Anna Vallverdú-Queralt, Cristina Delerue-Matos, Francisca Rodrigues

• DOI: 10.3390/bios13070722 2023

  The Fabrication of a La2Sn2O7/f-HNT Composite for Non-Enzymatic Electrochemical Detection of 3-Nitro-l-tyrosine in Biological Samples

  Balasubramanian Sriram, Sakthivel Kogularasu, Sea-Fue Wang, Guo-Ping Chang-Chien