515-P: Study to Evaluate the Relationship between Inpatient Glycemic Control as Measured by CGM and Wound Healing in Patients Admitted for Diabetic Foot Ulcer (DFU)

We performed a post-hoc analysis of hospitalized patients admitted with DFU enrolled in an inpatient continuous glucose monitor (CGM) study. Bivariate analysis was conducted between those with wound healing vs. non-healing over a 16-week period. Logistic regression was performed to assess the following CGM metrics and likelihood of wound healing: TIR (70-180 mg/dl), TAR (>180 mg/dl) and TBR (<70 mg/dl). Potential confounders included in the multivariate analysis were age, race and sex, history of peripheral arterial disease, renal failure, prior amputation, and ulcer duration. Results of patient characteristics are summarized in the Table. Of 230 patients enrolled in our CGM studies, 62 (27%) were admitted for DFU. Sixteen weeks after discharge, 9 (15%) patients were lost to follow-up, 13 (21%) had healed, and 39 (62%) had not healed. Of the non-healed, 10 (15%) had an amputation, 3 (4.7%) died, and 26 (41%) had a persistent ulcer. We did not find an association between the likelihood of healing and CGM derived glycemic metrics: fully adjusted models for TIR (OR 0.99, 95% CI 0.96-1.02), TAR (1.01 95% CI 0.98-1.04), and TBR (0.85; 95% CI 0.52-1.40). While glycemic control remains an important predictor of diabetes complications, we did not find an association between glycemic control in the hospital based on CGM metric and post-discharge healing.