492-P: Utility of Measures of Nerve Fiber Function and Structure for the Diagnosis of Diabetic Peripheral Neuropathy
CAROLINA M. CASELLINI, HENRI PARSON, COURTNY CUSHMAN, AMBER M. INGRAM, JORDAN L. PETTAWAY, TANEISHA SEARS, ELIAS S. SIRAJ- Endocrinology, Diabetes and Metabolism
- Internal Medicine
Introduction: Identifying diabetic neuropathy (DPN) in the clinic is challenging. The purpose of this study is to investigate the utility of various diagnostic tools for the detection of DPN
Methods: The following measures were assessed in controls and patients with type 2 diabetes with and without DPN: clinical neuropathy scores, quantitative sensory testing, corneal confocal microscopy, and sudomotor function. Receiver operating characteristics and areas under the curve with sensitivity and specificity were calculated
Results: See Table and Figure
Conclusions: Functional measures were more sensitive but less specific than structural ones. Similar to other studies, our study shows that no individual test is reliable per-se. Future studies are needed to investigate the best combination of tests for assessing DPN.
Disclosure
C.M.Casellini: None. H.Parson: None. C.Cushman: None. A.M.Ingram: None. J.L.Pettaway: None. T.Sears: None. E.S.Siraj: Research Support; Novo Nordisk, Speaker's Bureau; Novo Nordisk, Boehringer Ingelheim and Eli Lilly Alliance.