473-P: Differences in Carotid Arteriosclerosis according to Waist Circumference and Thigh Circumference Appear Differently in Diabetic Patients and Prediabetic Patients

This study investigated the relationships of thigh and waist circumference with the glycemic variability and carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM) and prediabetes. This observational study included 3,453 Korean patients with T2DM and prediabetes, in whom anthropometric measurements and carotid ultrasonography were conducted. Carotid plaque was defined as focal structures encroaching the arterial lumen by ≥ 0.5 mm or 50% of the surrounding IMT value or a thickness ≥1.5 mm. In men with T2DM, it was found that the larger the thigh circumference, the lower the risk of carotid plaque after adjustment for potential confounding variables. In women with T2DM, a similar tendency was observed before adjustment, but no statistically significant relationship was seen after adjustment. In women with T2DM, the presence of carotid plaque was higher in the thickest waist group compared to the reference group, but there is no statistical significance after adjustment. However, no difference in carotid arteriosclerosis according to waist and thigh circumference was found in both men and women in prediabetic patients. It suggests that the risk of cardiovascular disease according to the difference in body type such as waist circumference and thigh thickness may appear differently depending on the glucose status. However, further longitudinal studies are warranted.