435-P: Remnant-C as an Independent Risk Factor for End-Stage Renal Disease in Patients with Type 2 Diabetes—A Nationwide Population-Based Cohort Study

Few studies have investigated the association between remnant-C and the progression of diabetic nephropathy. We aimed to evaluate the association between remnant-C and the risk of newly developed end-stage renal disease (ESRD) in patients with type 2 diabetes in a nationwide cohort of Korean adults. The risk of incident ESRD according to remnant-C levels was analyzed by Cox proportional hazard models. During the median follow-up period of 9 years, 11,615 individuals (1.4% of the total population) developed ESRD. The serum concentrations of remnant-C was associated with 7% higher risk of ESRD per every 10 mg/dL increase. In multivariable-adjusted analyses, participants in the upper quartile of remnant-C had a higher risk of ESRD, with hazard ratios of 1.15 (95% CI 1.09-1.22) in the second quartile, 1.26 (95% CI 1.20-1.33) in the third quartile, and 1.47 (95% CI 1.40-1.55) in the fourth quartile, compared with the lowest quartile. Furthermore, the magnitude of the increased risk for incident ESRD in individuals with higher remnant-C quartiles was significant in participants aged 50 years or older. These results suggest that remnant-C concentration is an independent risk factor for the development of ESRD in patients with type 2 diabetes.