Francomano Dr. Davide, Dehò Prof. Federico, Capogrosso Prof. Paolo, La Vignera Prof. Sandro, Antonini Prof. Gabriele, Aversa Prof. Antonio

(312) PLATELET-RICH PLASMA (PRP) TREATMENT AND PENILE REJUVENATION IN PATIENTS WITH ERECTILE DYSFUNCTION: THE ROLE OF MEAN PLATELET VOLUME

  • Urology
  • Reproductive Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health

Abstract Objectives Erectile dysfunction (ED) is one a common disorder in adult males and current therapies are symptomatic and do not influence disease progression. By contrast, regenerative medicine may potentially reverse or stop the progression of ED and restore erectile capacity. We aimed to evaluate the clinical correlates of platelet function before platelet-rich plasma (PRP) injection and its potential efficacy in men with vascular ED poorly respondent to PDE5i. Methods To this purpose, 150 patients (Age: 51±16.7; mean IIEF5: 12±2.6; mean PSV: 32±5.5; Mean MPV=9.3±1.1) were submitted to a single-shot treatment of PRP. All patients were evaluated at baseline for mean platelet volume (MPV), and at baseline and 1 month after treatment for IIEF5 and dynamic penile duplex ultrasound (d-PDU) according to Aversa et al (Andrology, 2021; 9:1457-1466). Results All patients had a significant improvement in ED symptoms (IIEF5: 12±2.6 vs 19±3.0; p<0.0001) and a significant improvement at d-PDU (PSV: 32±5.5 vs 42±7.6; p<0.0001). The ROC analysis showed a significant accuracy (72.1%, C.I.64.0 - 80.2, p <0.0001) for MPV in identifying men clinically responding to PRP with favourable outcomes (+4 points in IIEF5 score). In particular, an MPV<8.95 was recognized as the best threshold with a sensitivity of 90% and specificity of 54.1%. Conclusions This study provides the first evidence that PRP outcomes correlate with baseline MPV in patients with ED and poorly responding to PDE5i. MPV below 8.95 identify patients with lower response to treatment that might benefit of re-treatment. Conflicts of Interest None

Need a simple solution for managing your BibTeX entries? Explore CiteDrive!

  • Web-based, modern reference management
  • Collaborate and share with fellow researchers
  • Integration with Overleaf
  • Comprehensive BibTeX/BibLaTeX support
  • Save articles and websites directly from your browser
  • Search for new articles from a database of tens of millions of references
Try out CiteDrive

More from our Archive