Vena Dr. Walter, Bianchi Dr. Nicola, Frizza Dr. Francesca, Rastrelli Prof. Giulia, Vignozzi Prof. Linda, Barbonetti Prof. Arcangelo, Mannucci Prof. Edoardo, Sforza Dr. Alessandra, Maggi Prof. Mario, Pizzocaro Dr. Alessandro, Corona Dr. Giovanni

(275) THE ROLE OF TESTOSTERONE TREATMENT IN PATIENTS WITH TYPE 2 DIABETES MELLITUS:RESULTS FROM A META-ANALYSIS STUDY

  • Urology
  • Reproductive Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
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Abstract Objectives Type 2 diabetes mellitus [T2DM] and hypogonadism are common conditions afflicting the aging male, often present together. The specific role of testosterone [T] replacement therapy [TRT] on glycometabolic profile and body composition, particularly in patients with T2DM, is still the object of an intense debate. The aim of the present study is to meta-analyze the role of TRT in T2DM considering all placebo and non-placebo-controlled randomized clinical trials [RCTs]. Methods An extensive Medline, Embase and Cochrane search was performed. We did not employ search software but hand-searched bibliographies of retrieved papers for additional references. All RCTs studies investigating the impact of TRT on glycometabolic outcomes without any restriction were included. Results Overall, 12 studies were available including 684 patients with a mean follow-up of 38.4 weeks. These trials differ in basal TT levels and type of T preparation used. In addition, only 10 were placebo controlled Conclusions The overall data analysis indicates that TRT favorably affects glycemic control in diabetic subjects reducing fasting glycaemia, HbA1c and HOMA index and decreasing triglyceride levels and fat mass. All these differences were confirmed when only placebo-controlled studies were evaluated, with the exception for HbA1c decrease, where only a trend towards a decrease was apparent. Conversely no effects on TRT on erectile function was observed. Conflicts of Interest No conflict of interest to delcare.

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