Boeri Dr. Luca, Pozzi Dr. Edoardo, Belladelli Dr. Federico, Fallara Dr. Giuseppe, Bertini Dr. Alessandro, Cilio Dr. Simone, Lanzaro Dr. Francesco, Candela Dr. Luigi, Corsini Dr. Christian, Raffo Dr. MAssimiliano, Cella Ludovica, Negri Fausto, Fanton Margherita, Capogrosso Dr. Paolo, Darma Dr. Alessia, Montorsi Prof. Francesco, Salonia Prof. Andrea

(155) THE CLINICAL PROFILE OF MEN WITH PREMATURE EJACULATION AT PRESENTATION HAS CHANGED OVER THE LAST FIFTEEN YEARS: analysis froma longitudinalstudy

  • Urology
  • Reproductive Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health

Abstract Objectives Patient’s characteristics at first medical evaluation for a specific sexual dysfunction (SD) are strongly correlated to the public awareness towards the specific disease and the availability of novel treatments. We aimed to assess the clinical characteristics of patients presenting for premature ejaculation (PE) as their primary medical complaint over a 15-year time frame Methods Data from 257 heterosexual men seeking first medical help for primary PE between 2008 and 2022 were analysed. Clinical data and serum hormones were collected. At baseline all patients completed the IIEF, the Beck Inventory for Depression (BDI), and the Premature Ejaculation Diagnostic Tool (PEDT). Relationship status was categorized as: single vs. stable sexual relationship. Descriptive statistics and linear regression analyses were permformed. Results Of all, 182) (71%) patients reported erectile dysfunction (ED) according to IIEF-EF scores. Across the 15-year time frame, patient’s age at presentation significantly decreased over time (p<0.001). Furthermore, depressive symptoms at BDI (p<0.001) and PE severity as scored with the PEDT (p<0.001) linearly decreased. When segregating the whole cohort into 5-year groups, age at presentation decreased from 2008-2012 to 2013-2017 (p=0.04) and further decreased between 2018-2022 (p=0.01). Similarly, baseline BDI scores decreased from 2008-2012 to 2018-2022 (all p<0.001). PE severity at first assessment has decreased since 2017 (p<0.01). Patients more frequently asked for medical attention for PE between 2018-2022 compared to 2013-2017 and 2008-2012 (p<0.001). Conclusions This longitudinal study showed that PE patients characteristic at first presentation has significantly changed throughout the last 15 years. Of note, age, PE severity and depressive symptoms showed has decreased overtime. Men in a stable sexual relationship were more likely to seek medical attention for PE in recent years. These results probably reflect the increased public awareness of PE; therefore, patients request PE consultation at younger age, with initial symptoms and with fewer psychological bother related to this condition Conflicts of Interest NA

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