Falcone Marco, Preto Dr. Mirko, Oderda Dr. Marco, Peretti Dr. Federica, Cirigliano Dr. Lorenzo, Ferro Dr. Ilaria, Plamadeala Dr. Natalia, Ceruti Dr. Carlo, Gontero Prof. Paolo

(130) INGUINAL LYMPHADENECTOMY FOR PENILE CANCER: RESULTS OF A PROSPECTIVE RANDOMIZED TRIAL COMPARING OPEN VS VIDEO LAPAROSCOPIC APPROACH

  • Urology
  • Reproductive Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
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Abstract Objectives To compare surgical and oncological outcomes between video laparoscopic (VEIL) and open inguinal lymphadenectomy (OIL) in patients affected by locally advanced penile cancer (PC). Methods Prospective randomized trial including patients underwent staging or radical inguinal lymphadenectomy for PC from October 2019 to March 2022. Patients were randomized to receive OIL on one groin and VEIL on the contralateral side. Operative time, intra and post-operative complication rate (according to Clavien-Dindo classification), number of removed and positive lymph nodes, disease-free survival (DFS) and overall survival (OS) were collected, compared and analyzed during the follow-up period. Results 28 inguinal lymphadenectomy procedures satisfied the inclusion and exclusion criteria, 14 (50%) OIL and 14 (50%) VEIL. Median follow-up was 14 months (IQR 6-17). No significant differences in terms of operative times, number of removed lymph nodes, 1-year DFS and 1-year OS were recorded in-between the two surgical approaches. Time to drainage removal was significantly shorter in the VEIL group (15days; IQR 13-17) than in the OIL group (27days; IQR 20-41; p <0.05). No intraoperative complications occurred. Long-term postoperative complications were recorded in 3 (21.4%) and in 8 (57.1%) groins respectively in the VEIL and in the OIL group (p <0.05). In the follow-up period, 2 patients died for PC. Conclusions VEIL may reduce postoperative complications when compared to OILL. Further high-powered studies are warranted to confirm these preliminary results. Conflicts of Interest None to declare.

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