DOI: 10.1039/d6np00038j ISSN: 0265-0568
Visual cycle-derived bisretinoids as endogenous natural products: enzyme-free formation, photochemical reactivity, and retinal degeneration
Hye Jin Kim, Janet R. Sparrow, Young Pyo JangThis review reframes retinal bisretinoids as autochthonous natural products, demonstrating how polyene electrophilicity and non-enzymatic aza-electrocyclization dictate their inevitable biogenesis and subsequent photochemical toxicity.