Visible‐Light‐Driven Three‐Component Reaction of Unactivated Alkenes Enables Access to Monofluoro γ‐Amino Acids

Abstract

A strategy for the synthesis of diverse protected α‐monofluoro‐γ‐amino acid derivatives has been developed. This reaction assembles a simple enamide, quinoxalin‐2(1H)‐one, and diethyl 2‐bromo‐2‐fluoromalonate through a three‐component reaction driven by visible light. The advantages of this protocol include the simplicity of its operation, mild conditions, high functional group tolerance, and applicability to a wide variety of substrates. The synthesis of this fluorine‐containing amino acid derivative has significant value for potential applications in medicinal chemistry and chemical biology.