DOI: 10.1093/jnci/51.2.473 ISSN: 1460-2105
Virus-Chemical Carcinogenesis: A Possible Viral Immunologic Influence on 3-Methylcholanthrene Sarcoma Induction
Carrie E. WhitmireSummary
The effects of neonatal infection with radiation leukemia virus (RadLV) on subcutaneous sarcoma induced by 3-methylcholanthrene (MCA) were studied in C57BL/6 mice. Results indicated that neonatal RadLV infection reduced the incidence of MCA-induced sarcomas, an effect similar to that previously demonstrated with formalin-inactivated RadLV vaccine. The incidence of RadLV-induced leukemias was low and unaffected by MCA treatment. The possible immunologic factors involved in the prevention of MCA sarcoma were discussed.