DOI: 10.1002/ejoc.202500183 ISSN: 1434-193X
User‐friendly and Green Procedure for a Photoinduced Wohl‐Ziegler Reaction
Florent Edde, Emmanuelle Drège, Laurent EvannoA convenient Wohl‐Ziegler bromination protocol using NBS under visible light in standard laboratory glassware is described. The monobromination reaction is efficient and selective over a wide range of substrates. Unlike previous studies, we prove that the use of a photocatalyst is unnecessary. The proposed protocol is simple to implement and applicable at the gram scale. The reaction takes place in a few tens of minutes at room temperature and offers an alternative to the use of CCl4, which is conventionally used for Wohl‐Ziegler bromination. Alternative conditions of bromination by CBr4 in the presence of a photocatalyst have also been investigated.