Update of the human early life exposome (HELIX) cohort: a European population-based exposome cohort—cohort profile
Parisa Montazeri, Léa Maitre, Sandra Andrušaitytė, Kristine Bjerve Gützkow, Kateřina Coufalíková, Roberta Davidson, Lorenzo Fabbri, Regina Grazuleviciene, Mònica Guxens, Barbara Heude, Norun Hjertager Krog, Lesley Hoyles, Marianna Karachaliou, Amrit Kaur Sakhi, Hector C Keun, Jana Klánová, Christos Lionis, Katerina Margetaki, Anne L McCartney, Rosemary RC McEachan, Cristina Balcells, Tim S Nawrot, Claire Philippat, Elliott Price, Joane Quentin, Pierre Jean Saulnier, Rémy Slama, Cathrine Thomsen, Jose Urquiza, Panagiotis A Vorkas, Dagmar Waiblinger, John Wright, Tiffany C Yang, Martine VrijheidPurpose
The Human Early Life Exposome (HELIX) cohort was established to assess a wide range of environmental exposures (the exposome) during early life and study the effects of the early life exposome on child and adolescent health outcomes and molecular omics signatures. Here, we describe the second follow-up of the HELIX cohort during adolescence, including measurements available and population characteristics.
Participants
HELIX is a collaborative study across six established and ongoing population-based birth cohort studies in six European countries (France, Greece, Lithuania, Norway, Spain and the United Kingdom). The cohort includes 1663 mother-child pairs recruited during pregnancy from 2003 to 2009 and followed up during childhood at 6–12 years from 2013 to 2016. This update summarises the most recent follow-up during adolescence (12–18 years) which took place from 2020 to 2022 and included 864 participants.
Findings to date
HELIX data have been used extensively in more than 100 publications, specifically pioneering the implementation of exposome approaches to address questions around the occurrence and effects of multiple exposures to real-life pollutant mixtures. These findings have improved our understanding of how multiple exposures co-exist and which exposures are driving the early-life exposome. Further, HELIX data have been used in exposome-wide discovery analyses to examine child health outcomes and used high-throughput omics techniques to characterise the internal exposome.
Future plans
Although no additional follow-up visits are currently planned, HELIX will remain an active exposome research resource for years to come. The cohort will leverage its comprehensive database and extensive biobank to investigate complex exposure-omics-health relationships and measure additional biological markers.