DOI: 10.1039/d6ra07686f ISSN: 2046-2069
Unrevealed oligoresveratrols from Shorea parvifolia root bark as xanthine oxidase inhibitors: isolation, in vitro bioassay, quantum studies and structure-ba
Axl Laurens Lukas Windah, Nanik Siti Aminah, Alfinda Novi Kristanti, Imam Siswanto, Geraldo Figo Hariyanto, Titah Aldila Budiastanti, Yoshiaki Takaya, Muhammad Ikhlas AbdjanOligoresveratrols from Shorea parvifolia potently inhibit xanthine oxidase, outperforming allopurinol. Integrated in vitro assays, DFT, docking, and MD simulations validate shorealactone and isoampelopsin D as stable, promising lead compounds.