Ultrathin Biointegrated Metal Organic Framework Nanofilms With Synergistic Antioxidant and Antibacterial Functions for Accelerated Diabetic Wound Healing

ABSTRACT

The precise management of diabetic wounds is severely hindered by a pathological microenvironment characterized by relentless bacterial infection and excessive reactive oxygen species (ROS). While metal–organic framework (MOF)‐based nanozymes offer immense catalytic potential for wound therapy, developing biointerfaces that seamlessly integrate these rigid crystals with soft tissues while maintaining multifaceted therapeutic efficacy remains a formidable materials challenge. Herein, we present an ultrathin, flexible, and bio‐integrable nanozyme platform constructed via the targeted deposition of a catalytic MOF (CuHHTP) onto a bacterial nanocellulose (BNC). This structural engineering effectively bridges the mechanical mismatch between conventional MOFs and biological tissues, endowing the resulting CuHHTP@BNC composite with robust wet‐tissue adhesion, exceptional conformability, and optimal breathability. The intrinsic nanozyme activity of the CuHHTP array provides pronounced superoxide dismutase (SOD)‐mimetic and hydroxyl radical scavenging capabilities, comprehensively reprogramming the oxidative wound microenvironment. Importantly, such dressing exhibits broad‐spectrum antibacterial activity against representative wound pathogens. In an infected diabetic mouse wound model, the CuHHTP@BNC dressing markedly accelerates wound closure, achieving over 98% healing within 13 days while significantly reducing inflammation and promoting tissue regeneration. This work establishes a robust paradigm for designing flexible, MOF‐based catalytic biointerfaces, highlighting their tremendous translational potential for complex chronic wound management and advanced wearable therapeutics.