DOI: 10.1002/ejoc.202301281 ISSN: 1434-193X
Trifluoromethylsulfinylation Reaction of Activated Arenes and Indoles with Trifluoromethanesulfinyl Chloride
Tian-Cheng Zhong, Min Jiang, Jin-Tao Liu- Organic Chemistry
- Physical and Theoretical Chemistry
The trifluoromethylsulfinylation reaction of activated arenes with trifluoromethanesulfinyl chloride (CF3SOCl) in the presence of Lewis acid was achieved under mild and solvent‐free conditions. A series of aryl trifluoromethyl sulfoxides were obtained in moderate to high yields. The protocol could be expanded to the perfluoroalkylsulfinylation of activated arenes, as well as the trifluoromethylsulfinylation of indoles without additive.