Trends in Ubiquitination Research in Brain Diseases from 1999 to 2024: A Bibliometric Analysis
Binqian Wu, Ruijia Duan, Ranran Tu, Man Luo, Lite Ge, Chunli Chen, Ming LuBackground:
Ubiquitination is a fundamental biological process that plays several critical roles in cellular regulation. In recent years, extensive research worldwide has investigated the involvement of ubiquitination in the pathogenesis of various brain diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), ischemic stroke, and glioblastoma (GBM). However, to date, no comprehensive bibliometric analysis has systematically examined the research landscape concerning the role of ubiquitination in brain diseases.
Methods:
A detailed exploration of the Web of Science Core Collection (WoSCC) database was carried out, encompassing studies from 1999 to 2024, to evaluate the interplay between ubiquitination mechanisms and various brain disorders. The database was retrieved on January 20, 2025. Bibliometric and visualization analyses were performed using various tools such as Microsoft Excel, VOSviewer, CiteSpace, the R package 'bibliometrix', and an online bibliometric platform.
Results:
A marked growth in scholarly articles investigating ubiquitination's role in brain diseases has been observed over the 25-year period from 1999 through 2024. A total of 1,658 articles were published in 539 journals. The United States leads in national research output, with the Chinese Academy of Sciences ranking first among all institutions in terms of publication output. Among authors, Ted M. Dawson has contributed the most articles, and the Journal of Biological Chemistry has the highest number of publications. Research on ubiquitination in brain diseases primarily focuses on AD, PD, ischemic stroke, and GBM.
Discussion:
The rapid expansion of this field highlights ubiquitination as a key regulatory mechanism in brain diseases. Future studies should focus on mechanistic depth and translational potential, particularly targeting ubiquitin related pathways for therapeutic intervention.
Conclusion:
Increasing attention is being paid to the research field exploring the relationship between brain diseases and ubiquitination. The insights from our findings may serve as a valuable reference for scholars interested in investigating ubiquitination in brain disorders in the future.