Transition Metal Catalyzed Asymmetric Reduction of 2-Pyridine Ketones

This graphical review provides a concise overview of transition metal catalysed asymmetric reduction of 2-ketopyridines to produce enantiopure hydroxy pyridines present in many chiral ligands and pharmaceuticals. Key methods include metal-catalyzed hydrogenation, transfer hydrogenation, and hydrosilylation, with a focus on sustainable catalysts like iron and manganese. This review serves as a foundation for future advancements in sustainable and enantioselective keto group reductions.