Transcranial 810 nm Pulsed Photobiomodulation Improves Learning and Reduces Aβ 42 Burden in APP/PS1 Mouse Model of Alzheimer’s Disease
Ye Zhang, Huiting Qiao, Zeping Lv, Rong Guo, Deyu Li, Wei Song, Daifa WangBackground:
Alzheimer’s disease (AD) is a leading cause of dementia in older adults, and effective and widely applicable treatment options remain limited. Photobiomodulation (PBM) has shown promise for AD. However, reported estimates of the delivered dose after transcranial propagation vary widely, limiting translation from animal models to clinical settings.
Objective:
Building on our team’s prior clinical findings, this study evaluated whether an 810 nm/10 Hz pulsed PBM regimen improves cognitive performance and reduces Aβ 42 burden in APP/PS1 mice.
Methods:
APP/PS1 mice received PBM using an 810 nm LED pulsed at 10 Hz. Irradiation was delivered for 540 sec/day, 6 days/week, for 7 weeks, with a scalp-surface power density of 0.025 W/cm 2 and an energy density of 13.5 J/cm 2 . Cognitive function was evaluated using the Morris water maze, and Aβ 42 burden was quantified by immunofluorescence.
Results:
Cortical and hippocampal Aβ
42
plaque burden was reduced,
Conclusions:
These findings support further evaluation of this 810 nm/10 Hz pulsed PBM regimen in AD mouse models and highlight the value of standardized PBM parameter reporting in preclinical studies.