DOI: 10.1002/adsc.202300625 ISSN:
Traceless Directing Group Enabled One‐Pot Regiospecific Synthesis of 2,3‐Diaryl‐4‐Fluoropyrroles
Dan Wang, Yu‐Ting Tian, Jing Nie, Marcin Jasiński, Xiaodong Tang, Jun‐An Ma- General Chemistry
Abstract
We describe a traceless group directed one‐pot regiospecific cycloaddition strategy to construct 4‐fluorinated pyrroles, which showcased promising anti‐inflammatory activity previously. By taking advantage of this protocol, a range of 4‐fluoropyrroles which are inaccessible via previous methods can be obtained, and a tentative reaction mechanism was proposed based on observed intermediates.