DOI: 10.4103/mjbl.mjbl_618_23 ISSN: 1812-156X

Total Antioxidant Status in Patients with Hypertriglyceridemia

Kajeen Rashid Hussein, Dhia Jaafar Al-Timimi, Sherwan Ferman Salih
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Abstract

Background:

Elevated blood triglyceride is a common metabolic disorder in the general population. Data regarding the association between triglycerides levels and antioxidant status are less well reported and controversial.

Objective:

The present study was thus carried out to detect antioxidant status and its relation to hypertriglyceridemia in patients attending hospital out-patient clinic.

Materials and Methods:

The study consists of two interrelated parts: The first was a cross-sectional study conducted on 644 patients attending hospital out-patient clinic of Department of Medicine at Azadi Teaching Hospital, Duhok. The second part was an interventional study that enrolled 40 patients had a complete laboratory examination with low antioxidant status and high triglycerides levels (TG > 150‐500 mg/dL). Total antioxidant capacity (TAC), lipid profile and anthropometric parameters were measured in fasting blood samples from all patients.

Results:

A significantly lower TAC ( P < 0.01) was found in the hypertriglyceridemia group compared with normal triglycerides group. In the hypertriglyceridemia patients, a negative correlation was observed with TAC ( P < 0.01). Antioxidant supplementation showed a significant decrease in triglycerides by (20.8%) and increased in serum antioxidant capacity by (77.1%). Diabetes mellitus was the best predictor of TG in both mild to moderate and severe groups.

Conclusion:

The results confirm that hypertriglyceridemia in conjunction with low antioxidant status may play a role in the pathogenesis of triglycerides-related pathologies in non-hospitalized patients, and antioxidant supplementation in this group may help correct abnormal levels of triglycerides.

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