TO DETERMINE THE INCIDENCE OF ACUTE KIDNEY INJURY IN PATIENTS OF COVID -19 ADMITTED IN TERTIARY CARE HOSPITALAND ITS IMPACT ON OUTCOME, BARABANKI

Aim: To determine the incidence of acute kidney injury in patients of Coronavirus-19 disease admitted in a tertiary care hospital in Barabanki and to assess its impact on outcome. Method: A total of 117 COVID-19 patients aged >18 years were enrolled in the study. Clinical severity of the disease was assessed. Assessment of AKI was done using KDIGO AKIWG criteria. Patients were followed-up till their hospital stay. Clinical course and outcome were noted in terms of oxygenation, mechanical ventilation and ICU need and mortality. Chi-square, Independent samples 't'- test and ANOVAwere used to compare the data. Results:Age of patients ranged from 18 to 90 years. Mean age of patients was 48.19±16.99 years, 65% of them were males. Mild, moderate and severe clinical severity was found in 31.6%, 29.1% and 39.3% patients. Incidence of AKI within 48- hr of admission was 26.5%. Atotal of 77 (65.8%) patients required oxygenation, mechanical ventilation was required in 52 (44.4%) cases. Atotal of 78 (66.7%) were admitted to ICU. There were 38 (32.5%) deaths. Incidence of AKI was signicantly associated with higher clinical severity, faster mean respiratory rate and lower mean oxygen saturation at the time of admission. AKI patients had signicantly higher mean serum creatinine, serum urea and serum potassium levels at admission as compared to non-AKI group patients. AKI patients had signicantly higher at admission median LDH and ferritin levels as compared to non-AKI group patients. Mortality rates were signicantly higher in AKI (61.3%) as compared to non-AKI group patients (22.1%). Conclusion: The ndings of the study showed that COVID-19 is associated with a high risk of AKI incidence which was signicantly associated with higher clinical severity, inammation and deranged renal parameters at admission. AKI also seemed to inuence the outcome and increased the risk of mortality