DOI: 10.1055/a-2159-4847 ISSN:
TMSN3 -promoted Shono oxidation of N,N-dialkyl amides
Wenlin Luo, Ruixing Zhang, Qi Xu, Shenyu Zheng, Meixia Liu, Shengmei Guo, Hu Cai- Organic Chemistry
An alkoxylation of N,N-dialkyl amides via the Shono reaction is developed, which offers a simple and efficient way to access N-adjacent-carbon-substituted amides. TMSN3 plays an essential role in this transformation and enables the reaction with broad substrate scope under mild conditions. This reaction proceeds under a lower current compared to the classical method and affords the products up to 91% yield. A possible mechanism is proposed according to control experiments.