Aims: To determine the prevalence and severity of thrombocytopenia among people living with HIV (PLWH), identify associated factors, and assess whether HIV-related associations persist after exclusion of major secondary causes.Methods: This retrospective study included adults with HIV followed at a tertiary-care center between January 2023 and July 2024. Baseline laboratory parameters obtained before initiation of antiretroviral therapy were used. Thrombocytopenia was defined as platelet count