Thiazolopyrimidine, a privileged scaffold: Recent updates on synthetic and pharmacological perspective in drug discovery

Abstract

Heterocyclic compounds are emerging as a privileged scaffold with a plethora of biological activities. In recent years, interest in thiazolopyrimidine chemistry has significantly increased due to its diverse pharmacological activities, such as anticancer, antimicrobial, analgesic, antioxidant, anti‐inflammatory, and so on. It provides various opportunities for structural modifications. The thiazolopyrimidine scaffold provides a key intermediate for the synthesis of various fused heterocycles and compounds of medicinal importance. By considering the role of this privileged scaffold, researchers have designed different synthetic protocols for the synthesis of thiazolopyrimidine derivatives. In the present review, several advancements in the synthetic methodology for the synthesis of thiazolopyrimidine derivatives with different substitutions have been discussed along with pharmacological activity, which provides key insights into the synthetic protocol and role of different substitutions on the core moiety for rational drug design and drug discovery.