THE ROLE OF SERUM FERRITIN AS ACUTE INFLAMMATORY MARKER IN COMPARISON TO CRP IN PATIENTS WITH SEPSIS

Introduction: Few biomarkers have been employed for diagnosis of sepsis, despite the fact that many have been studied for use in sepsis and are largely used as prognostic markers. None of them are sensitive or specic enough to be used frequently in clinical practise. However, even these have limited ability to distinguish sepsis from other inammatory disorders or to predict outcome. The most commonly utilised tests are PCT and CRP. Recently ferritin has also joined in this elite list, and the usefulness of it is least studied. Objectives:To compare the utility of serum ferritin, as acute inammatory marker, with CRP in patient with sepsis. Methodology: This is a Cross-sectional observational study. among 96 patients admitted with sepsis (diagnosed using Quick SOFA score), under the Department of General Medicine, Dhiraj General Hospital, Sumandeep Vidyapeeth- Smt. BK Shah Medical Institute & Research Center, Piparia, Vadodara 391760. The clinical and biochemical parameters (especially CRP and Ferritin) were observed and compared with the outcomes. Results: In our study, 78 (81.25%) had Recovered and 18 (18.75%) had Death. Klebsiella pneumoniae and Candida sp. had higher proportion of death. The mean levels of CRP and ferritin at 1st day and 3rd day were signicantly higher among the subjects who died. Other biochemical parameters such as Serum electrolytes, serum creatinine, and serum procalcitonin, SGPT, HbA1C, FBS and ESR were not signicantly related with the mortality. The area under the curve for Serum Ferritin (1st day) in predicting Outcome is 0.78 and for Serum Ferritin (3rd day) is 0.71. The area under the curve for CRP (1st day) in predicting Outcome is 0.688, and for CRP (3rd day) is 0.677. Conclusion: CRP and ferritin can be used as a prognostic marker in sepsis, of which serum ferritin has a greater predictive value.