The Role of Long Noncoding RNAs in Modulation of Stress Granules in Cancer

ABSTRACT

Stress granules are dynamic cellular structures that arise in response to stress. They play an important role in cancer cell survival by modulating multiple stress responses. Long noncoding RNAs (lncRNAs) have been identified as crucial regulators of stress granule (SG) dynamics, influencing cancer development and treatment resistance. LncRNAs play a role in the development and stability of stress granules, thereby enhancing cancer cells' ability to withstand severe conditions, such as chemotherapy. LncRNAs may promote the accumulation of pro‐apoptotic proteins within stress granules, thereby contributing to cancer cell persistence and potentially serving as a barrier to effective treatment. Recent findings highlight the significance of intricate interactions among lncRNAs, stress granules, and the tumour microenvironment (TME), underscoring the importance of targeting lncRNAs within stress granules to enhance the efficacy of current therapies. This review examines the role of lncRNAs in SG dynamics and their implications for cancer, with a focus on how lncRNAs regulate SG formation, function, and cancer cell resilience to stress.