The role of coagulation parameters in the assessment of acute pancreatitis severity: A retrospective study

Acute pancreatitis (AP) is a common and rapidly progressing disease of the digestive system. The occurrence of coagulation dysfunction is closely related to the severity of AP. Therefore, this study aims to explore the correlation and mechanism of early clinical coagulation function indicators in AP patients with the severity of the condition. Between January 2021 and May 2023, 60 cases of AP patients were divided into 2 groups: mild AP and severe AP. Coagulation parameters, including prothrombin time (PT), activated partial thromboplastin time, fibrinogen (FIB), and D-dimer (DD) levels, were measured. The Acute Physiology and Chronic Health Evaluation II score, Ranson score, and computerized tomography severity index score were used for Spearman linear correlation analysis of PT, activated partial thromboplastin time, FIB, and DD. Multifactor logistic stepwise regression analysis was conducted to identify the risk factors influencing the severity of AP. Receiver operating characteristic curve analysis was used to evaluate the diagnostic value of various indicators between the severe AP group and the mild AP group. Through bioinformatics methods, genes with significant differential expression and the pathophysiological processes associated with these genes were analyzed to explore the potential mechanisms and key genes involved in the progression of AP. PT > 12.2 seconds, FIB > 3.124 g/L, and DD > 0.97 mg/L are significantly correlated with the severity of AP and can serve as valuable indicators for assessing disease severity. Their potential mechanism may involve the CD177 and ALOX15/15-HETE signaling pathway, which affects the occurrence and development of AP by regulating coagulation function.